Leveraging Evolutionary Medicine Insights
Leveraging Evolutionary Medicine Insights
Two major challenges facing human civilization today are the maintenance and enhancement of curative and preventative treatments for infectious disease and cancer, and adequate provision of safe and nutritious food. A rising global population, increasing urbanization, and climate change challenge the sustainability of both endeavors. However, on top of that, the evolution of resistance and tolerance increasingly threaten the control pathogens and pests: where we thought we were close to the eradication of all infectious diseases “60 years ago, drug- resistant pathogens are one of the key public health challenges today. Drug resistance is an evolutionary problem at the heart. We aim to identify common ecological and evolutionary principles that underpin the selection and spread of drug resistance. These principles will be considered with a view to the design and testing of resistance management principles with broad application in agricultural and healthcare settings.
Published articles
Riveron, J.M., Huijben, S., Tchapga, W., Tchouakui, M., Wondji, M.J., Tchoupo, M., Irving, H., Cuamba, N., Maquina, M., Paaijmans, K. and Wondji, C.S. (2019). Escalation of Pyrethroid Resistance in the Malaria Vector Anopheles funestus Induces a Loss of Efficacy of Piperonyl Butoxide–Based Insecticide-Treated Nets in Mozambique. The Journal of Infectious Diseases, [online] 220(3), pp.467–475. | |
Paaijmans, K., Brustollin, M., Aranda, C., Eritja, R., Talavera, S., Pagès, N. and Huijben, S. (2019). Phenotypic insecticide resistance in arbovirus mosquito vectors in Catalonia and its capital Barcelona (Spain). PLOS ONE, 14(7), p.e0217860. | |
Smith-Aguasca, R., Gupta, H., Uberegui, E., Maquina, M., Saute, F., Paaijmans, K.P., Mayor, A. and Huijben, S. (2019). Mosquitoes as a feasible sentinel group for anti-malarial resistance surveillance by Next Generation Sequencing of Plasmodium falciparum. Malaria Journal, 18(1). | |
Huijben, S., Macete, E., Mombo-Ngoma, G., Ramharter, M., Kariuki, S., Desai, M., Shi, Y.P., Mwangoka, G., Massougbodji, A., Cot, M., Ndam, N.T., Uberegui, E., Gupta, H., Cisteró, P., Aponte, J.J., González, R., Menéndez, C. and Mayor, A. (2020). Counter-Selection of Antimalarial Resistance Polymorphisms by Intermittent Preventive Treatment in Pregnancy. The Journal of Infectious Diseases, [online] 221(2), pp.293–303. | |
Enahoro, I., Eikenberry, S., Gumel, A.B., Huijben, S. and Paaijmans, K. (2020). Long-lasting insecticidal nets and the quest for malaria eradication: a mathematical modeling approach. Journal of Mathematical Biology, 81(1), pp.113–158. | |
Paaijmans, K.P. and Huijben, S. (2020). Taking the ‘I’ out of LLINs: using insecticides in vector control tools other than long-lasting nets to fight malaria. Malaria Journal, 19(1). |