Identifying Key Evolutionary Processes

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Identifying Key Evolutionary Processes

Sedentary urban life is a novel environment for humans, who spent more than 99% of their evolutionary history as physically active hunter-gatherers. Recent reports suggest that many common chronic disease outcomes in industrialized populations, such as cardiovascular disease and obesity, are relatively rare in subsistence populations. Understanding how ecology interacts with lifestyle by examining diet, physical activity, parasite and pathogen load, and immune activation can provide insight into mismatches between post-industrial urban populations, and subsistence populations. This collaborative project will begin by building complex systems pathway models to look at the relationship between social, ecological, and immunological variables of interest and their link to metabolic pathology. This project uses an exploratory approach to appreciate the distinct pathways through which social factors may influence disease risk, consequent from the different ecological contexts (and thus environmental inputs) that vary between populations.

Published articles

Dinkel K, Costa ME, Kraft T, Cummings DK, Stieglitz J, Kaplan H, Gurven M, Trumble BC. Relationship of sanitation, water boiling, and mosquito nets to health biomarkers in a rural subsistence population. American Journal of Human Biology.
Stieglitz J, Trumble BC, Finch CE, Gurven M, Kaplan H, HORUS Study Team, Li D , Budoff MJ. (2019). Thoracic computed tomography reveals high prevalence of vertebral fracture and greater fracture risk with higher reproductive effort among forager-horticulturalists. eLife. [Impact Factor: 7.616]
Anderson A†, Trumble BC, Hove C, Kraft T, Kaplan H, Gurven M, Blackwell AD. Old friends and friendly fire: Pregnancy and hookworm infection among tropical horticulturalists. American Journal of Human Biology
Conferences in 2019: (1) Irimia A, Kaplan H, Trumble BC, Adrian JC, Maher AS, Rostowsky KA, Chowdhury NF, Sutherland ML, Sutherland JD, Allam AH, HORUS research team, Rodriguez DE, Cummings DK Garcia AR, Rowan CJ, Miyamoto MI, Alami S, Seabright E, Barisano G, Mack WJ, Chui HC , Stieglitz J, Law M, Gutierrez RQ, Gurven M, Finch CE. Using Computed Tomography to Assess Brain Volumetrics in Aging. Accepted for presentation at the Alzheimer's Association International Conference (AAIC19) 2019 (2) Gatz M, Kaplan H, Trumble BC, Thompson RC, Adrian JC, Sutherland ML, Sutherland JD, Chui HC, Rodriguez DE, Gutierrez RQ, Cummings DK, Seabright E, Lombardi GP, Michalik DE, Frohlich B, A, Highland H, Justice AE, North KE, Mack WJ, Thomas GS, Wann LS, Stieglitz J, Gurven M, Finch CE. APOE Genotype and Cognitive Performance in Tsimane and Moseten of Bolivia. Abstract accepted for presentation at the Alzheimer's Association International Conference (AAIC19) 2019 (3) Thompson RC, Trumble BC, Gurven M, Rowan C, Walsworth K, Neunuebel F, Allam A, Frohlich B, Wann LS, Michalik DE, Sutherland ML, Sutherland JD, Lombardi GP, Beheim B, Stieglitz, Narula J, Min JK, Finch CE, Thomas GS, Kaplan H. Frequent Aortic Valve Calcium in a Population with Minimal Atherosclerosis. ICNC 2019. (4) Dinkel K†, Costa ME, Stieglitz J, Kaplan H, Gurven M, Trumble BC. Latrine use, boiled water, and bed nets: associations between biomarkers of immune status and public health in a subsistence population. Human Biology Association 2019. (5) Woolard K†, Garcia AR*, Stieglitz J, Kaplan H, Gurven M, Trumble BC. The relative influence of perceived social capital and perceived material wealth on biomarkers of health in lowland Bolivia. Human Biology Association 2019. (6) Charifson M†, Cummings DK, Stieglitz J, Kaplan H, Gurven M, Trumble BC. Energetics and Fecundity: The Impact of Obesity and Insulin on Life-time Parity. Human Biology Association 2019. (7) Gettler LT, Bond A*, Trumble BC, Boyette A. Mothers’ and Fathers’ Testosterone and Oxytocin in a Small-Scale Fishing-Farming Community: Variation Based on Marital Conflict and Paternal Contributions. Human Biology Association 2019. (8) Dinkel K†, Costa ME, Stieglitz J, Kaplan H, Gurven M, Trumble BC. Associations between immune biomarkers and public health in a subsistence population. American Association for the Advancement of Science (AAAS) 2019 (9) Garcia AR*, Trumble BC, Marquez M, Gurven M, Blackwell AD. Diurnal neuroendocrine-immune regulation in ecological context: assessing relationships between cortisol and leukocytes among Honduran women. Human Biology Association 2019. (10) Garcia AR*, Murillo S, Trumble BC, Gurven M, Blackwell AD. Chronic stressors lead to dysregulated endocrine-immune function and diabetes risk in Honduran immigrant women. American Association of Physical Anthropology 2019. (11) Cummings DK, Trumble BC, Gurven M, Kaplan H. Forager-Horticulturalists more active, less sedentary than US population. American Association of Physical Anthropology 2019 (12) Trumble BC, Garcia AR*, Cummings D, Kraft TS, Stieglitz J, Gurven M, Kaplan H. Collecting Biomarkers of Chronic Diseases of Ageing in Field Settings. American Association of Physical Anthropology 2019 (13) Hové CM, Trumble BC, Anderson AS, Stieglitz J, Gurven M, Kaplan H, Blackwell AD. The flexibility of fetal tolerance: how immune function during pregnancy varies between two ecologically distinct populations. American Association of Physical Anthropology 2019 (14) Anderson AD, Blackwell AD, Trumble BC, Thompson R, Wann LS, Allam AH, Beheim B, Frohlich B, Sutherland ML, Sutherland JD, Stieglitz J, Eid Rodriguez D, Irimia A, Law M, Chui H, Gatz M, Michalik DE, Rowan CJ, Lombardi GP, Bedi R, Garcia AR, Min JK, Narula J, Finch CE, Gurven M, Thomas GS. Porotic cranial lesions in living forager-horticulturalists: theoretical pathways and preliminary evidence. American Association of Physical Anthropology 2019
) Charifson M†, Trumble BC (2019). Evolutionary origins of Polycystic Ovary Syndrome: An environmental mismatch disorder. Evolutionary Medicine and Public Health.
Gurven M, Trumble BC, Stieglitz J, Yetish G, Cummings D, Blackwell AD, Beheim B, Kaplan H, Pontzer H. (2019). Methodological differences cannot explain associations between health, anthropometrics and excess RMR. American Journal of Physical Anthropology.
Koster J, McElreath R, Hill K, Yu D, Shepard Jr G, van Vliet N, Gurven M, Kaplan H, Trumble BC, Bliege Bird R, Bird D, Codding B, Coad L, Pacheco-Cobos L, Winterhalder B, Lupo K, Schmitt D, Sillitoe P, Franzen M, Alvard M, Venkataraman V, Kraft T, Endicott K, Beckerman S, Marks S, Headland T, Pangau-Adam M, Siren A, Kramer K, Greaves R, Reyes-Garcia V, Gueze M, Duda R, Fernandez-Llamazares A, Gallois S, Napitupulu L, Ellen R, Ziker J, Nielsen M, Ready E, Healey C, Ross C. The Life History of Human Foraging: Cross-Cultural and Individual Variation. In Review- Preprint: https://doi.org/10.1101/574483
Gurven M, Trumble BC, Stieglitz J, Yetish G, Cummings D, Blackwell AD, Beheim B, Kaplan H, Pontzer H. (In Press). Methodological differences cannot explain associations between health, anthropometrics and excess RMR. American Journal of Physical Anthropology. [Impact Factor: 2.824]
Kraft T, Stieglitz J, Trumble BC, Martin M, Kaplan H, Gurven M. (2018) Nutrition transition in two lowland Bolivian subsistence populations. American Journal of Clinical Nutrition.