Identifying Key Evolutionary Processes
Identifying Key Evolutionary Processes
Sedentary urban life is a novel environment for humans, who spent more than 99% of their evolutionary history as physically active hunter-gatherers. Recent reports suggest that many common chronic disease outcomes in industrialized populations, such as cardiovascular disease and obesity, are relatively rare in subsistence populations. Understanding how ecology interacts with lifestyle by examining diet, physical activity, parasite and pathogen load, and immune activation can provide insight into mismatches between post-industrial urban populations, and subsistence populations. This collaborative project will begin by building complex systems pathway models to look at the relationship between social, ecological, and immunological variables of interest and their link to metabolic pathology. This project uses an exploratory approach to appreciate the distinct pathways through which social factors may influence disease risk, consequent from the different ecological contexts (and thus environmental inputs) that vary between populations.
Published articles
NIH/National Institute on Aging R01 Competitive Revision for Brain atrophy, cognitive impairment and Alzheimer’s in a low CVD-risk population. Co-PI, $2,902,118 | |
NIH/National Institute on Aging R01 Diversity Supplement for Brain atrophy, cognitive impairment and Alzheimer’s in a low CVD-risk population. PI, $195,000 | |
NIH/National Institute on Aging R01 COIVD-19 Supplement for Brain atrophy, cognitive impairment and Alzheimer’s in a low CVD-risk population. PI, $995,000, | |
Kraft T, Trumble BC, Kaplan, H, Garcia A*, Stieglitz J, Gurven MD. Physiological dysregulation and aging in evolutionary perspective. Philosophical Transactions B. [Impact Factor: 6.139] | |
Trumble BC, Stieglitz J, Jaeggi AV, Beheim BA, Schwartz M, Seabright E, Cummings D, Kaplan H, Gurven M. (2018). Associations between paternal hormones, crop losses, and family illness health following catastrophic flooding in lowland Bolivia. Physiology and Behavior. DOI: 10.1016/j.physbeh.2018.02.028 [Impact Factor: 3.033] | |
Garcia AR*, Blackwell AD, Trumble BC, Stieglitz J, Kaplan H, Gurven MD. Evidence for height and immune function tradeoffs among preadolescents in a high pathogen population. Evolution, Medicine, and Public Health. [Impact Factor: 4.4] | |
Garcia, AR*, Trumble BC, Kraft TS, Murillo S, Marquez M, Gurven MD, Blackwell AD. Does exposure to parasites modify relationships between diurnal cortisol and leukocytes among Honduran women? American Journal of Physical Anthropology. [Impact Factor: 2.824] | |
Hove CM†, Trumble BC, Anderson A†, Stieglitz J, Gurven M, Kaplan H, Blackwell AD. The Flexibility of Fetal Tolerance: Immune Function during pregnancy varies between ecologically distinct populations. Evolution, Medicine, and Public Health. [Impact Factor: 4.4] | |
Kaplan HS, Trumble BC, Stieglitz J, Mendez R, Gutierrez MC, Maito LM, Alami S, Kraft TS, Quispe RG, Copajira JA, Thompson RC, Thomas GS, Michalik DE, Eid DR, Gurven MD. (2020). Voluntary collective isolation as a best response to COVID-19 for indigenous populations? A case study and protocol from the Bolivian Amazon. The Lancet. [Impact Factor: 59.102] | |
Koster J, McElreath R, Hill K, Yu D, Shepard Jr G, van Vliet N, Gurven M, Kaplan H, Trumble BC, Bliege Bird R, Bird D, Codding B, Coad L, Pacheco-Cobos L, Winterhalder B, Lupo K, Schmitt D, Sillitoe P, Franzen M, Alvard M, Venkataraman V, Kraft T, Endicott K, Beckerman S, Marks S, Headland T, Pangau-Adam M, Siren A, Kramer K, Greaves R, Reyes-Garcia V, Gueze M, Duda R, Fernandez-Llamazares A, Gallois S, Napitupulu L, Ellen R, Ziker J, Nielsen M, Ready E, Healey C, Ross C. (2020). The Life History of Human Foraging: Cross-Cultural and Individual Variation. Science Advances. [Impact Factor: 12.804] | |
Trumble BC, Schneider-Crease I. (2020). Chronic Diseases of Aging in an Evolutionary Context. Evolutionary Medicine and Public Health. [Impact Factor: 4.4] | |
Dinkel K, Costa ME, Kraft T, Cummings DK, Stieglitz J, Kaplan H, Gurven M, Trumble BC. Relationship of sanitation, water boiling, and mosquito nets to health biomarkers in a rural subsistence population. American Journal of Human Biology. | |
Stieglitz J, Trumble BC, Finch CE, Gurven M, Kaplan H, HORUS Study Team, Li D , Budoff MJ. (2019). Thoracic computed tomography reveals high prevalence of vertebral fracture and greater fracture risk with higher reproductive effort among forager-horticulturalists. eLife. [Impact Factor: 7.616] | |
Anderson A†, Trumble BC, Hove C, Kraft T, Kaplan H, Gurven M, Blackwell AD. Old friends and friendly fire: Pregnancy and hookworm infection among tropical horticulturalists. American Journal of Human Biology | |
Conferences in 2019: (1) Irimia A, Kaplan H, Trumble BC, Adrian JC, Maher AS, Rostowsky KA, Chowdhury NF, Sutherland ML, Sutherland JD, Allam AH, HORUS research team, Rodriguez DE, Cummings DK Garcia AR, Rowan CJ, Miyamoto MI, Alami S, Seabright E, Barisano G, Mack WJ, Chui HC , Stieglitz J, Law M, Gutierrez RQ, Gurven M, Finch CE. Using Computed Tomography to Assess Brain Volumetrics in Aging. Accepted for presentation at the Alzheimer's Association International Conference (AAIC19) 2019 (2) Gatz M, Kaplan H, Trumble BC, Thompson RC, Adrian JC, Sutherland ML, Sutherland JD, Chui HC, Rodriguez DE, Gutierrez RQ, Cummings DK, Seabright E, Lombardi GP, Michalik DE, Frohlich B, A, Highland H, Justice AE, North KE, Mack WJ, Thomas GS, Wann LS, Stieglitz J, Gurven M, Finch CE. APOE Genotype and Cognitive Performance in Tsimane and Moseten of Bolivia. Abstract accepted for presentation at the Alzheimer's Association International Conference (AAIC19) 2019 (3) Thompson RC, Trumble BC, Gurven M, Rowan C, Walsworth K, Neunuebel F, Allam A, Frohlich B, Wann LS, Michalik DE, Sutherland ML, Sutherland JD, Lombardi GP, Beheim B, Stieglitz, Narula J, Min JK, Finch CE, Thomas GS, Kaplan H. Frequent Aortic Valve Calcium in a Population with Minimal Atherosclerosis. ICNC 2019. (4) Dinkel K†, Costa ME, Stieglitz J, Kaplan H, Gurven M, Trumble BC. Latrine use, boiled water, and bed nets: associations between biomarkers of immune status and public health in a subsistence population. Human Biology Association 2019. (5) Woolard K†, Garcia AR*, Stieglitz J, Kaplan H, Gurven M, Trumble BC. The relative influence of perceived social capital and perceived material wealth on biomarkers of health in lowland Bolivia. Human Biology Association 2019. (6) Charifson M†, Cummings DK, Stieglitz J, Kaplan H, Gurven M, Trumble BC. Energetics and Fecundity: The Impact of Obesity and Insulin on Life-time Parity. Human Biology Association 2019. (7) Gettler LT, Bond A*, Trumble BC, Boyette A. Mothers’ and Fathers’ Testosterone and Oxytocin in a Small-Scale Fishing-Farming Community: Variation Based on Marital Conflict and Paternal Contributions. Human Biology Association 2019. (8) Dinkel K†, Costa ME, Stieglitz J, Kaplan H, Gurven M, Trumble BC. Associations between immune biomarkers and public health in a subsistence population. American Association for the Advancement of Science (AAAS) 2019 (9) Garcia AR*, Trumble BC, Marquez M, Gurven M, Blackwell AD. Diurnal neuroendocrine-immune regulation in ecological context: assessing relationships between cortisol and leukocytes among Honduran women. Human Biology Association 2019. (10) Garcia AR*, Murillo S, Trumble BC, Gurven M, Blackwell AD. Chronic stressors lead to dysregulated endocrine-immune function and diabetes risk in Honduran immigrant women. American Association of Physical Anthropology 2019. (11) Cummings DK, Trumble BC, Gurven M, Kaplan H. Forager-Horticulturalists more active, less sedentary than US population. American Association of Physical Anthropology 2019 (12) Trumble BC, Garcia AR*, Cummings D, Kraft TS, Stieglitz J, Gurven M, Kaplan H. Collecting Biomarkers of Chronic Diseases of Ageing in Field Settings. American Association of Physical Anthropology 2019 (13) Hové CM, Trumble BC, Anderson AS, Stieglitz J, Gurven M, Kaplan H, Blackwell AD. The flexibility of fetal tolerance: how immune function during pregnancy varies between two ecologically distinct populations. American Association of Physical Anthropology 2019 (14) Anderson AD, Blackwell AD, Trumble BC, Thompson R, Wann LS, Allam AH, Beheim B, Frohlich B, Sutherland ML, Sutherland JD, Stieglitz J, Eid Rodriguez D, Irimia A, Law M, Chui H, Gatz M, Michalik DE, Rowan CJ, Lombardi GP, Bedi R, Garcia AR, Min JK, Narula J, Finch CE, Gurven M, Thomas GS. Porotic cranial lesions in living forager-horticulturalists: theoretical pathways and preliminary evidence. American Association of Physical Anthropology 2019 | |
Charifson M†, Trumble BC (2019). Evolutionary origins of Polycystic Ovary Syndrome: An environmental mismatch disorder. Evolutionary Medicine and Public Health. | |
Gurven M, Trumble BC, Stieglitz J, Yetish G, Cummings D, Blackwell AD, Beheim B, Kaplan H, Pontzer H. (2019). Methodological differences cannot explain associations between health, anthropometrics and excess RMR. American Journal of Physical Anthropology. | |
Gettler LT, Bond A*, Trumble BC, Boyette A. (2019). Mothers’ and Fathers’ Testosterone and Oxytocin in a Small-Scale Fishing-Farming Community: Variation Based on Marital Conflict and Paternal Contributions. Brain and Behavior. [Impact Factor: 2.219] | |
Trumble BC, Finch CE. (2019). The exposome in human evolution: from dust to diesel. The Quarterly Review of Biology. [Impact Factor: 2.321] | |
Kraft T, Stieglitz J, Trumble BC, Martin M, Kaplan H, Gurven M. (2018) Nutrition transition in two lowland Bolivian subsistence populations. American Journal of Clinical Nutrition. |